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4mg of colchicine is administered orally divided into one or two doses.

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If patients develop signs or symptoms that could indicate a blood cell dyscrasiasuch as feverstomatitissore throatprolonged bleedingbruising or skin disorderstreatment with colchicine should be immediately discontinued and a full haematological investigation should be conducted straight away.

Some drugs such as HMG-CoA reductase inhibitors and fibrates may increase the risk of myopathy when combined with colchicine capsulesComplaints of muscle pain or weakness could be an indication to check serum creatinine kinase levels for signs of myopathy.

Advise patients that muscle pain or weaknesstingling or numbness in fingers or toes may occur with colchicine capsules alone or when it is used with certain other drugsPatients developing any of these signs or symptoms must discontinue colchicine capsules and seek medical evaluation immediately.

What is the most important information I should know about colchicine capsules?

Patients with renal or hepatic impairment should not be given colchicine capsules with drugs that inhibit both P-glycoprotein and CYP3A4See CONTRAINDICATIONSCombining these dual inhibitors with colchicine capsules in patients with renal and hepatic impairment has resulted in life-threatening or fatal colchicine toxicity.

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