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Estrogens increase the risk of gallbladder diseaseDiscontinue estrogen if hypercalcemiasudden partial or complete loss of visionhypertriglyceridemiaor cholestatic jaundice occursPatients dependent on thyroid hormone replacement therapy should have their thyroid function monitored in order to maintain their free thyroid hormone levels in an acceptable rangeEndometriosis may be exacerbated in women treated post-hysterectomy with estrogen-alone therapyThe addition of progestins should be considered in these patients.
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1For treatment of moderate to severe vasomotor symptomsvulval and vaginal atrophy associated with the menopausethe lowest dose and regimen that will control symptoms should be chosen and medication should be discontinued as promptly as possible.
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