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Until more is knowncaution is advised in the use of danazol in the presence of known or suspected malignant diseasesee also contraindicationsBefore treatment initiationthe presence of hormone-dependent carcinoma should be excluded at least by careful clinical examinationas well as if breast nodules persist or enlarge during danazol treatmentIn the event of virilisationDanazol should be withdrawnWhilst androgenic reactions will generally prove reversiblecontinued use of danazol in the face of evident virilisation is likely to cause irreversible androgenic effects.

A temporary alteration of lipoproteins in the form of decreased high density lipoproteins and possibly increased low density lipoproteins has been reported during Danazol therapyThese alterations may be markedand prescribers should consider the potential impact on the risk of atherosclerosis and coronary artery disease in accordance with the potential benefit of the therapy to the patient.

A temporary alteration of lipoproteins in the form of decreased high density lipoproteins and possibly increased low density lipoproteins has been reported during Danazol therapyThese alterations may be markedand prescribers should consider the potential impact on the risk of atherosclerosis and coronary artery disease in accordance with the potential benefit of the therapy to the patient.

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since danazol is metabolized by the liver, it cannot be used by patients with liver disease, and in patients receiving long-term therapy, liver function must be monitored on a periodic basis.

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