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Nephrolithiasis/urolithiasis has occurred with CRIXIVAN therapyThe cumulative frequency of nephrolithiasis is substantially higher in pediatric patients29than in adult patients12.4range across individual trials4.7to 34.4The cumulative frequency of nephrolithiasis events increases with increasing exposure to CRIXIVANhoweverthe risk over time remains relatively constantIn some casesnephrolithiasis/urolithiasis has been associated with renal insufficiency or acute renal failurepyelonephritis with or without bacteremiaIf signs or symptoms of nephrolithiasis/urolithiasis occurincluding flank painwith or without hematuria or microscopic hematuriatemporary interruptione.g13 daysor discontinuation of therapy may be consideredAdequate hydration is recommended in all patients treated with CRIXIVANSee ADVERSE REACTIONS and DOSAGE AND ADMINISTRATIONNephrolithiasis/Urolithiasis

Researchers are studying the lipodystrophy syndrome to try to discover ways of helping people with HIV avoid or reduce this problemTo find out more about options for managing aspects of the lipodystrophy syndromesee CATIE’s A Practical Guide to HIV Drug Side Effects

Indinavir is a type of anti-HIV drug called a protease inhibitorThe most common side effects of indinavir can include nauseaheadachediarrheavomitingand weaknessIndinavir can also cause kidney stonesbut drinking a minimum of 1.5 litres of water dailyin addition to your regular intake of other fluidscan help reduce this complication.

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pimavanserin major because pimavanserin is primarily metabolized by cyp3a4 and cyp3a5, the manufacturer recommends that the pimavanserin dose be reduced to 17 mg day po in patients receiving strong inhibitors of cyp3a4 such as indinavir.

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