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Inform patients not to use low-dose aspirin concomitantly with Ponstel until they talk to their healthcare providersee PRECAUTIONSDrug Interactions

Known hypersensitivitye.ganaphylactic reactions and serious skin reactionsto mefenamic acid or any components of the drug productsee WARNINGSAnaphylactic ReactionsSerious Skin ReactionsHistory of asthmaurticariaor other allergic-type reactions after taking aspirin or other NSAIDsSeveresometimes fatalanaphylactic reactions to NSAIDs have been reported in such patientssee WARNINGSAnaphylactic ReactionExacerbation of Asthma Related to Aspirin SensitivityIn the setting of coronary artery bypass graftCABGsurgerysee WARNINGSCardiovascular Thrombotic Events

This drug passes into breast milk and may have undesirable effects on a nursing infantConsult your doctor before breast-feeding.

When NSAIDs were administered with aspirinthe protein binding of NSAIDs were reducedalthough the clearance of free NSAID was not alteredThe clinical significance of this interaction is not knownSee Table 2 for clinically significant drug interactions of NSAIDs with aspirinsee PRECAUTIONSDrug Interactions

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in december 2000, we signed an agreement with a third-party to manufacture and supply us with ponstel upon receiving fda approval.

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