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Dosage depends on the severity of the disease and the response of the patientPatients should be continually monitored for signs that indicate dosage adjustment is necessarysuch as remissions or exacerbations of the disease and stresssurgeryinfectiontraumasee WARNINGS and PRECAUTIONSGeneral

Prolonged use of corticosteroids may produce posterior subcapsular cataractsglaucoma with possible damage to the optic nervesand may enhance the establishment of secondary ocular infections due to fungi or viruses.

The lowest possible dose of corticosteroid should be used to control the condition being treatedA gradual reduction in dosage should be made when possible.

Corticosteroids may affect the nitrobluetetrazolium test for bacterial infection and produce false-negative results.

In larger dosesfludrocortisone acetate inhibits endogenous adrenal cortical secretionthymic activityand pituitary corticotropin excretionpromotes the deposition of liver glycogenandunless protein intake is adequateinduces negative nitrogen balance.

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