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Patients should be instructed to report symptoms of muscle painweaknessor tendernessIf such symptoms developcreatine kinase should be measuredand if elevatedsimvastatin should be discontinuedThe value of regular monitoring of creatine kinase is not knownIn some studieselevations in creatine kinase occurred in up to 5.2of patients on simvastatinIn most casesthese elevations were mildtransientand not associated with clinical symptomsRef]

Muscle breakdown is also a serious problemIf statins cause the muscle protein myoglobin to leech into the bloodstreamit can shut down the kidneyswhich aren’t equipped to filter out that proteinThat condition is called rhabdomyolysisand can be potentially fatal.

When diet and exercise aren’t enoughshould you turn to drugsLearn cholesterol basicsdrug classesand available drugs along.

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