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There are certain forms of pulmonary hypertensionwhich are serious in nature and worsen with timeso much so that they are even fatal at timesIt also includes forms which are non curable in naturehoweverin order to improve the quality of lifesymptoms can be reduced with proper treatmentThe treatment for pulmonary hypertension is often complex and it takes some time to find the most appropriate treatment and requires extensive follow-up careYour doctor might also need to change your treatment if it’s no longer effectiveHoweverwhen pulmonary hypertension is caused by another conditionyour doctor will treat the underlying cause whenever possible.
If it’s not suiting uU can change to krimson 35 or dronisThey r better tolerated.
Following oral administrationCPA is completely absorbed in a wide dose rangeThe ingestion of CPA+EE attains a maximum serum level of 15 ng CPAml at 1.6 hoursThereafterdrug serum levels decrease in two disposition phases characterized by half-lives of 0.8 hours and 2.3 daysThe total clearance of CPA from serum was determined to be 3.6 ml/min/kgCPA is metabolized by various pathwaysincluding hydroxylations and conjugationsThe main metabolite in human plasma is the 15 beta-hydroxy derivative.
In rare cases benign and in even rarer cases malignant liver tumours leading in isolated cases to life-threatening intra-abdominal haemorrhage have been observed after the use of hormonal substances such as CPA+EEIf severe upper abdominal complaintsliver enlargement or signs of intra-abdominal haemorrhage occura liver tumour should be included in the differential diagnosis.
A meta-analysis from 54 epidemiological studies reported that there is a slightly increased relative riskRR1.24of having breast cancer diagnosed in women who are currently using COCsThe observed pattern of increased risk may be due to an earlier diagnosis of breast cancer in COC usersthe biological effects of COCs or a combination of bothThe additional breast cancers diagnosed in current users of COCs or in women who have used COCs in the last ten years are more likely to be localized to the breast than those in women who never used COCs.
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