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You will take letrozole once a day by mouth and imatinib mesylate twice a day by mouth until intolerable side effects occur or until your tumor grows furtherYou will stop the treatment if your tumor grows or intolerable side effects occur.

Store this medication at room temperature in the original containerIf you prefer to use a pillboxdiscuss this with your oncology pharmacistAsk your oncology team where to return any unused medication for disposalDo not flush down the toilet or throw in the trashKeep containers out of reach of children and pets.

Letrozole comes in tablet form and is taken by mouth once dailyLetrozole can be taken with or without foodIf you miss a dosetake it as soon as you rememberIf it is almost time for your next doseskip the missed doseDo not take two doses at the same timeDo not stop taking letrozole without talking to your healthcare team.

To determine the efficacy of Letrozole plus Imatinib Mesylate in patients with ER and or PgR positive metastatic breast cancerEfficacy will be measured by the rate of clinical tumor responseTo determine the safety and tolerability of Letrozole plus Imatinib Mesylate in patients with metastatic breast cancerTo determine the time to disease progression and overall survival in patients with metastatic breast cancer who are treated with Letrozole plus Imatinib Mesylate.

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