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A very serious allergic reaction to this drug is rareHoweverget medical help right away if you notice any symptoms of a serious allergic reactionincludingrashitching/swellingespecially of the face/tongue/throatsevere dizzinesstrouble breathing.

ISMP Canada received a report of a medication incident in which Advagrafan extended-release formulation of tacrolimus for oral administrationwas dispensed to a patient instead of the intended Prografan immediate-release oral formulation of the same drugRecent reports from the United Kingdom 12 and Europe 34 have documented mix-ups between Prograf and Advagraf and have outlined concerns about the outcomes of such incidentsAccording to these warningsmix-ups between Prograf and Advagraf have led to serious harmincluding cases of biopsy-confirmed acute rejection of transplanted organs and toxic effects due to overexposureAlthough this incident occurred in a community pharmacyit is an important alert for hospital pharmacists about the potential for serious patient harm if these drugs are mistakenly interchanged.

Anaphylactic reactions have occurred with injectables containing castor oil derivativessuch as Prograf injectionsee WARNINGS AND PRECAUTIONS

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following antibody induction, if prograf therapy is initiated orally, the recommended starting dose is 0.

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