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Limited data in cats and rabbits showed retinal changes in some animals with doses as low as 126 mg/kg/dayonly about 3 times the recommended human doseadministered for several days to two weeks.

Nauseavomitingdiarrheaor dizziness may occurIf any of these effects persist or worsentell your doctor or pharmacist promptly.

After an intravenous dose of 1 gthe plasma concentration time curve shows a triexponential decay with a half-life of about 2 hours for the terminal elimination phaseThe initial volume of distribution is about 9 to 12 litersUrinary excretion is the main route of elimination via glomerular filtrationOverall renal clearance is equal to overall plasma clearance110 to 116 mL/minand more than 95of the dose is excreted in the urine as unchanged drugExcretion of tranexamic acid is about 90at 24 hours after intravenous administration of 10 mg per kg body weight.

Reproduction studies performed in miceratsand rabbits have not revealed any evidence of impaired fertility or adverse effects on the fetus due to tranexamic acid.

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