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There may be an increased risk of elevated blood sugar levels and diabetes with olanzapine as well as the other antipsychotic medications in its classPatients should be tested during treatment for elevated blood sugarAdditionallypersons with risk factors for diabetesincluding obesity or a family history of diabetesshould have their fasting levels of blood sugar tested before starting treatment and periodically throughout treatment to detect the onset of diabetesAny patient developing symptoms that suggest diabetes during treatment should be tested for diabetes.

Jay WMarksMDis a board-certified internist and gastroenterologistHe graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

Bipolar I DisorderManic or Mixed EpisodesOlanzapine as Adjunct to Lithium or ValproateIn a study of patients who were already tolerating either lithium or valproate as monotherapydiscontinuation rates due to adverse reactions were 11for the combination of oral olanzapine with lithium or valproate compared to 2for patients who remained on lithium or valproate monotherapyDiscontinuations with the combination of oral olanzapine and lithium or valproate that occurred in more than 1 patient weresomnolence3weight gain1and peripheral edema1

Olanzapine oral tablet can interact with other medicationsvitaminsor herbs you may be takingAn interaction is when a substance changes the way a drug worksThis can be harmful or prevent the drug from working well.

BACKGROUNDOlanzapine is an atypical antipsychotic that is reported to be effective without producing the disabling extrapyramidal side effects associated with the oldertypical antipsychotic drugs.

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commonly used second-generation atypical antipsychotic drugs include aripiprazole abilify , clozapine clozaril , olanzapine zyprexa , quetiapine seroquel , quetiapine fumarate seroquel xr , risperidone risperdal , long-acting risperidone risperdal consta , ziprasidone geodon , and paliperidone invega .

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